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-synuclein, which is a primary ingredient of Lewy bodies, in PARK one in 1997 and parkin in PARK 2 in 1998, which is an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) anxiety, propose that dysfunction of the intracellular proteinase methods, including ubiquitin-proteasome procedure or lysosomal technique, which eliminates unwanted toxi